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Simulation of PID Control Schemes for Closed-Loop Deep Brain Stimulation


Eleanor M. Dunn, Madeleine Lowery

Publication Type: 
Refereed Conference Meeting Proceeding
— Recent studies have shown that specific motor symptoms of Parkinson's disease (PD) are correlated with oscillatory beta-band (12-30 Hz) activity in the basal ganglia. Deep brain stimulation (DBS) is an established therapy for PD, but is currently applied in an open-loop configuration. A computational model of the cortico-basal ganglia network was developed to systematically test the performance of five separate linear control schemes for closed-loop DBS. Each controller modulated the amplitude of DBS using the oscillatory activity in the basal ganglia as a biomarker. All controllers yielded a reduction in current and demonstrated a response to the suppression and resurgence of oscillations within the network. The model developed here can be further used to design and test more complex non-linear control schemes.
Conference Name: 
6t h Annua l Internationa l IEE E EMB S Conferenc e o n Neura l Engineerin g
Digital Object Identifer (DOI): 
Publication Date: 
Conference Location: 
United States of America
Research Group: 
National University of Ireland, Dublin (UCD)
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