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Simulating the Therapeutic Effects of Deep Brain Stimulation in Rodents Using a Cortico-basal Ganglia Network and Volume Conductor Model

Authors: 

Christian Schmidt, Eleanor Dunn, Madeleine Lowery, Ursula Van Rienen

Publication Type: 
Refereed Conference Meeting Proceeding
Abstract: 
Models of the cortico-basal ganglia network and volume conductor models of the brain can help to gain insight into the mechanisms of action of deep brain stimulation (DBS). In this study, the coupling of a network model under Parkinsonian conditions to the extracellular field distribution obtained from a 3D finite element model of a rodent’s brain during DBS is presented. This coupled model is used to investigate the influence of variations in the electrical properties and thickness of the encapsulation tissue, which is formed around the electrode body after implantation, on the suppression of oscillatory neural activity during DBS. First results suggest that variation in the properties of the encapsulation tissue, within the range examined, have a limited influence on the suppression of pathological oscillatory activity during DBS in rodents.
Conference Name: 
7th Annual International IEEE EMBS Conference on Neural Engineering
Digital Object Identifer (DOI): 
10.1109/NER.2015.7146757
Publication Date: 
22/04/2015
Conference Location: 
Germany
Research Group: 
Institution: 
National University of Ireland, Dublin (UCD)
Open access repository: 
No
Publication document: