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Biosensing in dermal interstitial fluid using microneedle based electrochemical devices

Authors: 

Julia Madden, Conor O'Mahony, Michael Thompson, Alan O'Riordan, Paul Galvin

Publication Type: 
Refereed Original Article
Abstract: 
This article explores recent advances in the development of electrochemical biosensors on microneedle platforms towards on-device sensing of biomarkers present in dermal interstitial fluid. The integration of a biosensor with a microneedle platform opens the possibility for minimally invasive bio-chemical detection or continuous monitoring within the dermal interstitial fluid. An introduction to interstitial fluid is provided placing emphasis on sampling methods that have been employed to extract and/or sample tissue fluid for analysis. We look briefly at microneedle technologies used to extract dermal interstitial fluid for subsequent analysis. Successive content will focus on microneedle technologies which have been integrated with electrochemical biosensors for the quantification of various metabolites, electrolytes and other miscellaneous entities known to be present in the dermal interstitial fluid. The review concludes with some of the key challenges and opportunities faced by this next-generation wearable sensing technology.
Digital Object Identifer (DOI): 
10.1016/j.sbsr.2020.100348
Publication Status: 
Published
Date Accepted for Publication: 
Wednesday, 13 May, 2020
Publication Date: 
31/08/2020
Journal: 
Sensing and Bio-Sensing Research
Volume: 
29
Issue: 
Aug 2020
Pages: 
100348
Institution: 
Tyndall National Institute
Open access repository: 
Yes